The key residues in the immunodominant region 353-363 of human thyroid peroxidase were identified.

Localization of the immunodominant region on human thyroid peroxidase in autoimmune thyroid diseases: an update

Recent studies in the field of autoimmune thyroid diseases have largely focused on the delineation of B-cell auto-epitopes recognized by the main autoantigens to improve our understanding of how these molecules are seen by the immune system. Among these autoantigens which are targeted by autoantibodies during the development of autoimmune thyroid diseases, thyroid peroxidase is a major player. ...

Highly Conformational Epitope Facet on the Native Antigen Containing a Human Monoclonal Autoantibody Locates a Peroxidase: Epitopic Footprinting with a Immunodominant Region on Thyroid Search for the Autoantibody

Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ.

The most common organ-specific autoimmune disease in humans involves the thyroid. Autoantibodies against thyroid peroxidase (TPO) are present in the sera of virtually all patients with active disease. We report the molecular cloning of the genes for 30 high-affinity, IgG-class human autoantibodies to TPO from thyroid-infiltrating B cells. Analysis of the putative germline genes used for the TPO...

A study on the wind erosion potential of agricultural lands after crop harvesting (Case study: Damghan Region)

Aeolian process and subsequently soil erosion are key factors in dryland environments. Such phenomena are related not only to geoecological factors (lithology, topography, and climatology) but also to land-use and plant cover changes. Formation of new sand dunes in Damghan explains the development of human activities over the past. The aim of this study is to explain the land use changes and th...

Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test

Background: Anti-thyroid peroxidase antibody (anti-TPO antibody) is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. Thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism. Objective: To evaluate the relationship between serum levels of anti-TPO ...